Drug Information
| Drug Generic Name | DACARBAZINE |
| Drug Class | PROTEASOME INHIBITOR |
| Chapter | Malignant Disease & Immunosuppression |
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Indications: metastatic melanoma and, in combination therapy, soft tissue sarcomas. It is also a component of a commonly used second line combination for Hodgkin's disease [ABVD-doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine]. Cautions: caution in handling - irritant to skin and mucous membranes. Contra-indications: pregnancy Side effect: myelosuppression; very severe nausea and vomiting; rarely liver necrosis due to hepatic vein thrombosis; irritant to skin and tissues. |
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